＊Helmchen F, Imoto K, Sakmann B. Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons. (pdf)  Biophys J 70: 1069-1081, 1996.

Helmchen F, Borst JG, Sakmann B. Calcium dynamics associated with a single action potential in a CNS presynaptic terminal. (pdf)  Biophys J 72: 1458-1471, 1997.

Kirischuk S, Verkhratsky A. [Ca2+]i recordings from neural cells in acutely isolated cerebellar slices employing differential loading of the membrane-permeant form of the calcium indicator fura-2 （pdf）Pflugers Arch 431:977-983, 1996. 小脳のさまざまな細胞（含むバーグマングリア）から記録

McPherson DR, McClellan AD, O'Donovan MJ. Optical imaging of neuronal activity in tissue labeled by retrograde transport of Calcium Green Dextran（pdf） Brain Res Protoc 1:157-164, 1997. デキストラン結合色素を逆行性にロード。Calcium Green

Schwartz TH, Rabinowitz D, Unni V, Kumar VS, Smetters DK, Tsiola A, Yuste R. Networks of coactive neurons in developing layer 1（pdf） Neuron 20:541-552, 1998. 単一細胞解像度で相関を取った最初の論文。関連論文はこちら（pdf）。Fura-2

Wong RO. Calcium imaging and multielectrode recordings of global patterns of activity in the developing nervous system. Histochem J 30:217-229, 1998.

＊Smetters D, Majewska A, Yuste R. Detecting action potentials in neuronal populations with calcium imaging（pdf） Methods 18:215-221, 1999. 活動電位とカルシウム上昇。Fura-2

Takahashi A, Camacho P, Lechleiter JD, Herman B. Measurement of intracellular calcium. (pdf) Physiol Rev 79: 1089-1125, 1999.

＊Mammano F, Canepari M, Capello G, Ijaduola RB, Cunei A, Ying L, Fratnik F, Colavita A. An optical recording system based on a fast CCD sensor for biological imaging（pdf） Cell Calcium 25:115-123, 1999. 1.25ms/frameという超高速撮影を成功させた論文。Fluo-3

＊Canepari M, Mammano F Imaging neuronal calcium fluorescence at high spatio-temporal resolution（pdf） J Neurosci Methods 87:1-11, 1999. 活動電位（と発火頻度）とカルシウム上昇の関係を詳細に解析した論文。Calcium Green-1 & Calcium Crimson。Lips&Kellerによるこれでもスパイク数との相関を検討している。

Garaschuk O, Linn J, Eilers J, Konnerth A. Large-scale oscillatory calcium waves in the immature cortex（pdf）Nat Neurosci 3:452-459, 2000. 幼若マウス皮質の同期オシレーション。Fura-2 & Fura-PE3

Barallobre MJ, Del Rio JA, Alcantara S, Borrell V, Aguado F, Ruiz M, Carmona MA, Martin M, Fabre M, Yuste R, Tessier-Lavigne M, Soriano E. Aberrant development of hippocampal circuits and altered neural activity in netrin 1-deficient mice（pdf） Development 127:4797-4810, 2000. 遺伝子改変動物に初めて応用した論文。Fura-2

＊Peterlin ZA, Kozloski J, Mao BQ, Tsiola A, Yuste R. Optical probing of neuronal circuits with calcium indicators（pdf） Proc Natl Acad Sci U S A. 97:3619-3624, 2000. シナプス結合している細胞を探す方法「光学プロービング」を提唱。Fura-2

Canepari M, Mammano F, Kachalsky SG, Rahamimoff R, Cherubini E GABA- and glutamate-mediated network activity in the hippocampus of neonatal and juvenile rats revealed by fast calcium imaging（pdf） Cell Calcium 27:25-33, 2000. P14で海馬スライスを染めている。Fluo-3

Thomas D, Tovey SC, Collins TJ, Bootman MD, Berridge MJ, Lipp P. A comparison of fluorescent Ca2+ indicator properties and their use in measuring elementary and global Ca2+ signals. Cell Calcium 28: 213-223, 2000.

Bolsover S, Ibrahim O, O'luanaigh N, Williams H, Cockcroft S. Use of fluorescent Ca2+ dyes with green fluorescent protein and its variants: problems and solutions. (pdf)  Biochem J 356: 345-352, 2001.

＊Kozloski J, Hamzei-Sichani F, Yuste R. Stereotyped position of local synaptic targets in neocortex（pdf） Science 293:868-872, 2001. Fura-2

Badea T, Goldberg J, Mao B, Yuste R. Calcium imaging of epileptiform events with single-cell resolution（pdf） J Neurobiol 48:215-227, 2001. Fura-2

＊Mao BQ, Hamzei-Sichani F, Aronov D, Froemke RC, Yuste R. Dynamics of spontaneous activity in neocortical slices（pdf） Neuron 32:883-898, 2001. 高速イメージング。スパイク・シークエンスを示した最初の論文。Fura-2

Tashiro A, Goldberg J, Yuste R. Calcium oscillations in neocortical astrocytes under epileptiform conditions（pdf） J Neurobiol 50:45-55, 2002 ニューロンとグリアを分離。Fura-2

Aguado F, Espinosa-Parrilla JF, Carmona MA, Soriano E. Neuronal activity regulates correlated network properties of spontaneous calcium transients in astrocytes in situ（pdf） J Neurosci 22:9430-9444, 2002. GFP発現マウスを利用してニューロンとグリアを分離。Fura-2

Beierlein M, Fall CP, Rinzel J, Yuste R. Thalamocortical bursts trigger recurrent activity in neocortical networks: layer 4 as a frequency-dependent gate（pdf） J Neurosci 22:9885-9894, 2002. Fura-2

Ghozland S, Aguado F, Espinosa-Parrilla JF, Soriano E, Maldonado R. Spontaneous network activity of cerebellar granule neurons: impairment by in vivo chronic cannabinoid administration（pdf） Eur J Neurosci 16:641-651, 2002. 小脳顆粒細胞でのイメージング。Fura-2

Kettunen P, Demas J, Lohmann C, Kasthuri N, Gong Y, Wong RO, Gan WB. Imaging calcium dynamics in the nervous system by means of ballistic delivery of indicators（pdf） J Neurosci Methods 119:37-43, 2002. 6ヶ月齢の海馬にジーンガンで色素をロード。Calcium Green-1 & Oregon Green 488 BAPTA-1。デキストランを使った続報のこちらやこちらも参考に。

＊Cossart R, Aronov D, Yuste R. Attractor dynamics of network UP states in the neocortex（pdf） Nature 423:283-288, 2003. ２光子では初 Fura-2

Morita M, Higuchi C, Moto T, Kozuka N, Susuki J, Itofusa R, Yamashita J, Kudo Y. Dual regulation of calcium oscillation in astrocytes by growth factors and pro-inflammatory cytokines via the mitogen-activated protein kinase cascade（pdf） J Neurosci 23:10944-10952, 2003. 海馬スライス培養を使った最初の論文。Fluo-4

Morita M, Susuki J, Moto T, Higuchi C, Kudo Y. A novel method to quantify calcium response pattern and oscillation using fura2 and acridine orange（pdf） J Pharmacol Sci 94:25-30, 2004. アクリジンオレンジで細胞体の位置を自動検出すつ方法を提案。Fura-2

Corlew R, Bosma MM, Moody WJ Spontaneous, synchronous electrical activity in neonatal mouse cortical neurones（pdf） J Physiol 560:377-390, 2004. Fluo-4

Kawamura M, Gachet C, Inoue K, Kato F. Direct excitation of inhibitory interneurons by extracellular ATP mediated by P2Y1 receptors in the hippocampal slice（pdf） J Neurosci 24:10835-10845, 2004. P7-8の海馬スライスCA3から記録 Fluo-4

＊MacLean JN, Watson BO, Aaron GB, Yuste R. Internal dynamics determine the cortical response to thalamic stimulation（pdf） Neuron 48:811-823, 2005. Fura-2

Murayama M, Miyazaki K, Kudo Y, Miyakawa H, Inoue M. Optical monitoring of progressive synchronization in dentate granule cells during population burst activities（pdf）Eur J Neurosci 21:3349-3360, 2005. 海馬顆粒細胞にDyeを逆行性にロード。Oregon Green 488 BAPTA-1

Bonnot A, Mentis GZ, Skoch J, O'Donovan MJ. Electroporation loading of calcium-sensitive dyes into the CNS（pdf） J Neurophysiol 93:1793-808, 2005. 電気穿孔法で色素をロード。Calcium Green

＊Diez-Garcia J, Matsushita S, Mutoh H, Nakai J, Ohkura M, Yokoyama J, Dimitrov D, Knopfel T. Activation of cerebellar parallel fibers monitored in transgenic mice expressing a fluorescent Ca2+ indicator protein（pdf） Eur J Neurosci 22:627-635, 2005. カルシウム蛍光タンパクのtransgenicマウス G-CaMP2

＊Zha XM, Green SH, Dailey ME. Regulation of hippocampal synapse remodeling by epileptiform activity. Mol Cell Neurosci 29: 494-506, 2005.

Carmona MA, Pozas E, Martinez A, Espinosa-Parrilla JF, Soriano E, Aguado F. Age-dependent spontaneous hyperexcitability and impairment of GABAergic function in the hippocampus of mice lacking trkB （pdf）. Cereb Cortex 16:47-63, 2006. Fura-2

Feinerman O, Moses E.. Transport of information along unidimensional layered networks of dissociated hippocampal neurons and implications for rate coding（pdf） J Neurosci. 26:4526-4534, 2006. カルシウム上昇の大きさを発火率としている。Fluo-4

＊Aaron G, Yuste R. Reverse optical probing (ROPING) of neocortical circuits（pdf） Synapse 60:437-440, 2006. プレシナプス細胞を探す技術「ROPING」 Fura-2

Kapoor V, Urban NN. Glomerulus-specific, long-latency activity in the olfactory bulb granule cell network glomerulus（pdf）J Neurosci 26:11709-11719, 2006. 嗅球顆粒細胞のネットワーク解析。Fura-2, Fura-4

Osanai M, Yamada N, Yagi T. Long-lasting spontaneous calcium transients in the striatal cells. Neurosci Lett 402: 81-85, 2006.

Trevelyan AJ, Sussillo D, Watson BO, Yuste R. Modular propagation of epileptiform activity: evidence for an inhibitory veto in neocortex.  (pdf)  J Neurosci 26: 12447-12455, 2006.

＊Salome R, Kremer Y, Dieudonne S, Leger JF, Krichevsky O, Wyart C, Chatenay D, Bourdieu L.. Ultrafast random-access scanning in two-photon microscopy using acousto-optic deflectors（pdf） J. Neurosci. Methods 154, 161-174, 2006. 二光子とAODを使った高速スキャン（ただし培養海馬神経細胞での実験） Oregon Green 488 BAPTA-1

Zheng J, Lee S, Zhou ZJ. A transient network of intrinsically bursting starburst cells underlies the generation of retinal waves. (pdf)  Nat Neurosci 9: 363-371, 2006.

Wilson JM, Dombeck DA, Rios MD, Harris-Warrick RM, Brownstone RM. Two-photon calcium imaging of network activity in XFP expressing neurons in the mouse（pdf） J. Neurophysiol. 97:3118-3125, 2007. 二光子でGFPと緑色蛍光指示薬の同時に使用した Fluo-3, Fura-2

＊Crepel V, Aronov D, Jorquera I, Represa A, Ben-Ari Y, Cossart R. A parturition-associated nonsynaptic coherent activity pattern in the developing hippocampus（pdf） Neuron 54:105-120, 2007. 高速ビーム二光子で海馬標本から観察 Fura-2


In Vivo

＊Stosiek C, Garaschuk O, Holthoff K, Konnerth A. In vivo two-photon calcium imaging of neuronal networks（pdf） Proc Natl Acad Sci U S A 100:7319-7324, 2003.　初めのvivoへの応用（著者からもらったMethodはこちら）。Calcium Green-1 & Fura-2 & Fluo-4 & Indo-1 AM & Fura-PE3 & Fura Red & Oregon Green 488 BAPTA-1 & Magnesium Green

O'Donovan MJ, Bonnot A, Wenner P, Mentis GZ. Calcium imaging of network function in the developing spinal cord. Cell Calcium 37: 443-450, 2005.

Sullivan MR, Nimmerjahn A, Sarkisov DV, Helmchen F, Wang SS. In vivo calcium imaging of circuit activity in cerebellar cortex（pdf） J Neurophysiol 94:1636-1644, 2005　小脳でのイメージング。Oregon Green 488 BAPTA-1

＊Nimmerjahn A, Kirchhoff F, Kerr JN, Helmchen F. Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo（pdf） Nat Methods 1:31-37, 2004 スルフォローダミン101を初めてアストロサイトの選択的ラベルに使った論文。Oregon Green 488 BAPTA-1

＊Ohki K, Chung S, Ch'ng YH, Kara P, Reid RC. Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex（pdf） Nature 433:597-603, 2005. ラット＆ネコ視覚野。Oregon Green 488 BAPTA-1

＊Adelsberger H, Garaschuk O, Konnerth A. Cortical calcium waves in resting newborn mice.
Nat Neurosci 8:988-990, 2005（pdf） 光ファイバーを初めて使用した論文。覚醒下の動物で初めて成功した論文。Oregon Green 488 BAPTA-1

＊Hasan MT, Friedrich RW, Euler T, Larkum ME, Giese G, Both M, Duebel J, Waters J, Bujard H, Griesbeck O, Tsien RY, Nagai T, Miyawaki A, Denk W. Functional fluorescent Ca2+ indicator proteins in transgenic mice under TET control（pdf） PLoS Biol 2:e163, 2004. カルシウム蛍光タンパクのconditional transgenicマウス Camgaroo-2。Svobodaラボのこちらも参考のこと。＊＊DrosophilaではWangらのこちらも有名。G-CaMP。

＊Kerr JN, Greenberg D, Helmchen F. Imaging input and output of neocortical networks in vivo （pdf）Proc Natl Acad Sci U S A 102:14063-14068, 2005. 入力と出力の相関を初めて取った。Oregon Green 488 BAPTA-1

Garaschuk O, Milos RI, Konnerth A. Targeted bulk-loading of fluorescent indicators for two-photon brain imaging in vivo. (pdf)  Nat Protoc 1: 380-386, 2006.

＊Yaksi E., Friedrich RW. Reconstruction of firing rate changes across neuronal populations by temporally deconvolved Calcium imaging（pdf） 時間的逆重畳法による発火頻度変化の再構成。rhodo-2

Ohki K, Chung S, Kara P, Hubener M, Bonhoeffer T, Reid RC. Highly ordered arrangement of single neurons in orientation pinwheels（pdf） Nature 442:925-928, 2006.Pinwheelの可視化 Oregon Green 488 BAPTA-1

Diez-Garcia J, Akemann W, Knopfel T. In vivo calcium imaging from genetically specified target cells in mouse cerebellum. Neuroimage 34: 859-869, 2007.

＊Gobel W, Kampa BM, Helmchen F. Imaging cellular network dynamics in three dimensions using fast 3D laser scanning（pdf） Nat. Methods 4:73-79, 2007. ピエゾを使った高速３Dスキャン Oregon Green 488 BAPTA-1

Gobel W, Helmchen F. New angles on neuronal dendrites in vivo. J Neurophysiol 98: 3770-3779, 2007. *

Heim N, Garaschuk O, Friedrich MW, Mank M, Milos RI, Kovalchuk Y, Konnerth A, Griesbeck O. Improved calcium imaging in transgenic mice expressing a troponin C-based biosensor. (pdf)  Nat Methods 4: 127-129, 2007.

Kerr JN, de Kock CP, Greenberg DS, Bruno RM, Sakmann B, Helmchen F. Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex. J Neurosci 27: 13316-13328, 2007. *

Lin BJ, Chen TW, Schild D. Cell type-specific relationships between spiking and [Ca2+]i in neurons of the Xenopus tadpole olfactory bulb. J Physiol 582: 163-175, 2007.

Mrsic-Flogel TD, Hofer SB, Ohki K, Reid RC, Bonhoeffer T, Hubener M. Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity. (pdf)  Neuron. 54: 961-972, 2007.

Murayama M, Perez-Garci E, Luscher HR, Larkum ME. Fiberoptic system for recording dendritic calcium signals in layer 5 neocortical pyramidal cells in freely moving rats. J Neurophysiol 98: 1791-1805, 2007.

＊Nagayama S, Zeng S, Xiong W, Fletcher ML, Masurkar AV, Davis DJ, Pieribone VA, Chen WR. In vivo simultaneous tracing and Ca(2+) imaging of local neuronal circuits. (pdf)  Neuron 53: 789-803, 2007.

Nevian T, Helmchen F. Calcium indicator loading of neurons using single-cell electroporation. Pflugers Arch 454: 675-688, 2007.

Nikolenko V, Poskanzer KE, Yuste R. Two-photon photostimulation and imaging of neural circuits. (pdf)  Nat Methods 4: 943-950, 2007.

Yaksi E, Judkewitz B, Friedrich RW. Topological Reorganization of Odor Representations in the Olfactory Bulb. (pdf)  PLoS Biol 5: e178, 2007

Sohya K, Kameyama K, Yanagawa Y, Obata K, Tsumoto T. GABAergic Neurons Are Less Selective to Stimulus Orientation than Excitatory Neurons in Layer II/III of Visual Cortex, as Revealed by In Vivo Functional Ca2+ Imaging in Transgenic Mice （pdf） J. Neurosci. 27:2145-2149, 2007. GAD67-GFPマウスで興奮性と抑制性を分離しながらV1マップを構築 Fura-2

Sato TR, Gray NW, Mainen ZF, Svoboda K. The Functional Microarchitecture of the Mouse Barrel Cortex （pdf）. PLoS Biol. 5:e189, 2007. バレル皮質の応答と自発活動 Fluo-4 AM

＊Dombeck DA, Khabba AN, Collman F, Adelman TL, Tank DW. Imaging large-scale neural activity with cellular resolution in awake, mobile mice （pdf）. Neuron 56:43?57, 2007. 頭部を固定したまま相対歩行可能な装置を開発 Calcium Green-1-AM

Berger T, Borgdorff A, Crochet S, Neubauer FB, Lefort S, Fauvet B, Ferezou I, Carleton A, Luscher HR, Petersen CC. Combined voltage and calcium epifluorescence imaging in vitro and in vivo reveals subthreshold and suprathreshold dynamics of mouse barrel cortex (pdf) J Neurophysiol. 97:3751-3762, 2007.

Carrillo-Reid L, Tecuapetla F, Tapia D, Hernandez-Cruz A, Galarraga E, Drucker-Colin R, Bargas J. Encoding network states by striatal cell assemblies (pdf) J Neurophysiol 99: 1435-1450, 2008.

Eichhoff G, Busche MA, Garaschuk O. In vivo calcium imaging of the aging and diseased brain (pdf) Eur J Nucl Med Mol Imaging 35: S99-106, 2008.

＊Holekamp TF, Turaga D, Holy TE. Fast three-dimensional fluorescence imaging of activity in neural populations by objective-coupled planar illumination microscopy (pdf)  Neuron 57: 661-672, 2008.




総説

Froemke RC, Kumar VS, Czkwianianc P, Yuste R. Analysis of multineuronal activation patterns from calcium-imaging experiments in brain slices（pdf） Trends Cardiovasc Med. 12:247-252, 2002.

Brecht M, Fee MS, Garaschuk O, Helmchen F, Margrie TW, Svoboda K, Osten P. Novel approaches to monitor and manipulate single neurons in vivo（pdf） J Neurosci 24:9223-9227, 2004.

Baker BJ, Kosmidis EK, Vucinic D, Falk CX, Cohen LB, Djurisic M, Zecevic D. Imaging brain activity with voltage- and calcium-sensitive dyes（pdf） Cell Mol Neurobiol 25:245-82, 2005.

Cossart R, Ikegaya Y, Yuste R. Calcium imaging of cortical networks dynamics（pdf） Cell Calcium 37:451-457, 2005.

＊Takahashi, N., Sasaki, T., Usami, A., Matsuk：i, N., Ikegaya, Y. Watching neuronal neuronal circuit dynamics through functional multineuron calcium imaging (fMCI)(pdf) Neurosci. Res., 58:219-225, 2007.

Gobel W, Helmchen F. In vivo calcium imaging of neural network function(pdf) Physiology (Bethesda). 22:358-365, 2007.



池谷関係

＊Ikegaya Y, Aaron G, Cossart R, Aronov D, Lampl I, Ferster D, Yuste R. Synfire chains and cortical songs: temporal modules of cortical activity（pdf） Science. 304:559-564, 2004. Fluo-4

＊Ikegaya Y, Le Bon-Jego M, Yuste R. Large-scale imaging of cortical network activity with calcium indicators（pdf） Neurosci Res 52:132-138, 2005. Fluo-4 & Oregon Green 488 BAPTA-1

Sasaki T, Kimura R, Tsukamoto M, Matsuki N, Ikegaya Y. Integrative spike dynamics of rat CA1 neurons: a multineuronal imaging study（pdf） J Physiol 574:283-290, 2006. Oregon Green 488 BAPTA-1

Sasaki, T., Matsuki, N., Ikegaya, Y. Metastability of active CA3 networks(pdf) J. Neurosci., 27:517-528, 2007. Oregon Green 488 BAPTA-1

Tsukamoto-Yasui M, Sasaki T, Matsumoto W, Hasegawa A, Toyoda T, Usami A, Kubota Y, Ochiai T, Hori T, Matsuki N, Ikegaya Y. Active hippocampal networks undergo spontaneous synaptic modification.(pdf) PLoS ONE. 2:e1250, 2007.

Usami A, Sasaki T, Satoh N, Akiba T, Yokoshima S, Fukuyama T, Yamatsugu K, Kanai M, Shibasaki M, Matsuki N, Ikegaya Y. Oseltamivir enhances hippocampal network synchronization.(pdf) J Pharmacol Sci. 106:659-662, 2008. Oregon Green 488 BAPTA-1